Science & Technology

Multi-Hallmark
Molecular Platform

We map Andean phytochemistry against every mechanism of aging — not one pathway, but the whole system. Our platform is built on the López-Otín 12-Hallmarks framework (Cell, 2023).

The Framework

12 Hallmarks of Aging.
One Platform.

Each hallmark represents a distinct biological mechanism of aging. Color indicates how our current pipeline addresses it.

Primary
Epigenetic Alterations
DNMT modulation, histone acetylation
→ Piceatannol · Theobromine
Primary
Cellular Senescence
SASP suppression, p21/p16 regulation
→ Withaperuvin O
Primary
Mitochondrial Dysfunction
ROS scavenging, biogenesis support
→ Betalains · Piceatannol
Primary
Deregulated Nutrient Sensing
SIRT1–NAD⁺ axis, mTOR modulation
→ Piceatannol (SIRT1 activator)
Antagonistic
Chronic Inflammation
NF-κB inhibition, cytokine balance
→ Piceatannol · Withanolides
Antagonistic
Loss of Proteostasis
Autophagy support, protein quality
→ Piceatannol (evidence review)
Primary
Disabled Macroautophagy
mTOR–AMPK pathway regulation
→ Theobromine (under investigation)
Integrative
Genomic Instability
DNA repair support, antioxidant defense
→ Betalains
Integrative
Telomere Attrition
Oxidative stress mitigation
→ Indirect evidence
Antagonistic
Dysbiosis
Microbiome modulation
→ Under investigation
Integrative
Altered Intercellular Comm.
Paracrine signaling, exosome biology
→ Withanolides (indirect)
Antagonistic
Stem Cell Exhaustion
Tissue regeneration support
→ Research pipeline
■ Primary Hallmarks ■ Antagonistic ■ Integrative
Pipeline Deep Dive

Each Molecule. Every Mechanism.

Select a candidate to explore the bioactivity profile, evidence base, and hallmark mapping.

Piceatannol
Passiflora edulis · Maracuyá (Passion Fruit) Seed
STILBENOID · CAS 10083-24-6 · ≥2% STANDARDIZED

A hydroxylated analogue of resveratrol, Piceatannol is our primary cosmeceutical candidate. Extracted from passion fruit seeds — a circular bioeconomy waste stream — it demonstrates superior bioavailability and broader receptor binding compared to resveratrol, with particular affinity for SIRT1 activation. Standardized at ≥2%, it is our most commercially advanced molecule.

Clinical Evidence
RCT data: 8% increase in skin hydration, 7% increase in elasticity after topical application. Keratinocyte bioassay confirms SIRT1 upregulation at physiologically relevant concentrations.
Epigenetic Evidence
SIRT1 activation drives deacetylation of H3K9, H3K56 — key epigenetic marks associated with cellular aging and UV stress response in skin.
SIRT1 Activator Anti-Inflammatory Waste Valorization COSMOS Track
Hallmark Activity Map
H1
Epigenetic Alterations
SIRT1 → H3K9/H3K56 deacetylation
H4
Deregulated Nutrient Sensing
SIRT1–NAD⁺ axis activation
H5
Chronic Inflammaging
NF-κB inhibition, IL-6 ↓
H6
Loss of Proteostasis
Autophagy support (evidence review)
H3
Mitochondrial Dysfunction
ROS scavenging, membrane stability
Withaperuvin Pool
Physalis peruviana · Uvilla (Cape Gooseberry)
WITHANOLIDE COMPLEX · WITHAPERUVIN O (2025 NOVEL)

A complex of withanolides derived from Physalis peruviana, the Andean golden berry. The 2025 characterization of Withaperuvin O represents a first-in-class Andean senomorphic candidate — a compound that modulates rather than eliminates senescent cells, preserving tissue homeostasis. This is our most novel and scientifically differentiated molecule.

2025 Discovery
Withaperuvin O identified and characterized in 2025 — novel withanolide with demonstrated senomorphic activity. Mechanism mapping in progress against SASP (Senescence-Associated Secretory Phenotype) suppression pathways.
Known Withanolide Evidence
Broader withanolide class (incl. Withaferin A) shows immunomodulatory and anti-senescence activity. NF-κB and HIF-1α pathway modulation documented across multiple studies.
Novel 2025 Senomorphic SASP Modulation IP Potential
Hallmark Activity Map
H2
Cellular Senescence
SASP suppression, p21/p16 reg.
H5
Chronic Inflammaging
NF-κB and HIF-1α modulation
H11
Altered Intercellular Comm.
Paracrine senescence suppression
Theobromine + Betalains
Theobroma cacao (aromatic) · Physalis peruviana
METHYLXANTHINE + NITROGEN-CONTAINING PIGMENTS

Two complementary molecules that together address epigenetic aging and mitochondrial health. Theobromine from Ecuador's premium aromatic cacao correlates with GrimAge epigenetic clock deceleration in two independent human cohorts (King's College, 2025). Betalains from uvilla provide potent antioxidant and mitochondrial support.

King's College London · 2025
Theobromine associated with epigenetic age deceleration across two human cohorts. GrimAge clock analysis: p=3.99×10⁻⁶. One of the strongest diet–epigenetics associations reported to date.
Betalain Evidence
Betacyanins and betaxanthins demonstrate DPPH radical scavenging IC₅₀ values below 0.5 mg/mL. Mitochondrial membrane potential preservation in oxidative stress models.
Epigenetic Clock GrimAge Correlation Mitochondria Antioxidant
Hallmark Activity Map
H1
Epigenetic Alterations
GrimAge clock deceleration
H3
Mitochondrial Dysfunction
Betalain · membrane protection
H8
Genomic Instability
ROS scavenging · DNA protection
H7
Disabled Macroautophagy
mTOR pathway (under investigation)
In the Lab

HPLC Characterization
in Action

Lab Process · HPLC Analysis
High-Performance Liquid Chromatography for Piceatannol standardization and quality control. Each batch verified against reference standards to confirm ≥2% Piceatannol concentration.
From Field to Formula

The Phytandina Process

01
Species Selection
Phytochemical mapping of endemic Andean superfruits against aging hallmarks
02
Waste Valorization
Extraction from agro-industrial residues — seeds, peels, pulp byproducts
03
HPLC Analysis
Quantitative characterization and standardization of bioactive compounds
04
In Vitro Validation
Keratinocyte, fibroblast bioassays. SIRT1, NF-κB pathway confirmation
05
B2B Licensing
Standardized extracts licensed to ingredient houses and cosmeceutical brands
Intellectual Property

Defensible Moats.
First-Mover Position.

🧪
Proprietary Standardization Methods

HPLC-verified extraction protocols achieving ≥2% Piceatannol concentration — a specification standard not commercially available elsewhere in the Andean ingredient market.

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Access to Endemic Botanical Material

Established relationships with Andean producers for Physalis peruviana, Passiflora edulis, and Theobroma cacao (aromatic). Supply chain control is a structural competitive advantage.

📋
COSMOS Certification Track

Certification pathway in progress, targeting COSMOS-standard organic cosmetic ingredient certification — a prerequisite for premium European and North American B2B channels.

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Withaperuvin O — Novel Characterization

The 2025 identification of Withaperuvin O represents a first-in-class characterization from the Physalis genus. This compound has no established commercial supply chain — we built it.